I imagine that it gets harder to discover new stuff if one is restricted to only looking in areas that are likely to make money. And if one needs billions of dollars to make a discovery, then one is looking in the wrong place, I think.
In their element: The science of science
Speaking of "positing questions," here's one for you: why are "the little people" not able to challenge the status quo, if the status quo doesn't work for them? I think we all know the answer to that, don't we?